SHAPE: Clubbed Nails Clubbed nails are hard to miss, and they are not to be taken lightly -- this nail condition can signal a serious illness, says Steele. "Clubbing of the nails is typically a sign of long-standing or severe cardiovascular or lung disease and poor oxygenation," says Steele. And the list only goes on -- clubbed nails can also signal cyanotic congenital heart disease, cystic fibrosis, and chronic inflammatory bowel disease. All of these diseases cause the small arteries in the fingertips to dilate, which enlarges the tissues of the nail beds and causes the fingernails to club.
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