The Process To understand why combination therapies are your best bet in reducing hyperpigmentation, it's important to know what's going on under the surface of your skin. Special skin cells called melanocytes produce melanin, the natural pigment found in skin. Melanocytes do this by housing cellular vehicles called melanosomes, which are responsible for the first step in melanin production. When inflammation occurs (caused by the sun's powerful rays or a pimple-popping gone awry, for example), melanin production is triggered within melanocytes. This all starts with the enzyme tyrosinase, which turns the amino acid tyrosine into melanin inside melanosomes.
Once melanin is synthesized, melanosomes pass through the outer tips of melanocytes to transfer melanin (a process known as melanogenisis) into the other skin cells. The end result: more melanin, aka hyperpigmentation, which you might refer to as an age spot or acne scar.
We all have the same number of melanocytes, but the size and distribution of melanosomes vary from person to person; the larger and more clustered these melanosomes are, the darker the resulting spot will be.
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