The Best No. 4: Sucralose (aka Splenda) It seems we can have our cake and eat it, too. This zero-calorie sugar substitute has shown no harmful effects to humans. It also holds up well when heated, so you can safely add it to your grandma's famous whoopie pie recipe. But keep in mind, foods tend to bake faster when you've used sucralose, says Holly Kistler, RD, registered dietician at Cederquist Medical Wellness Center in Naples, Fla.
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