Sure, The Organic Pharmacy Gene Expression Serum, $330, is a splurge, but this skin tightening serum addresses basically every skin concern -- not just sagging. It contains a vegetable peptide to tighten loose skin by controlling the release of Progerin, a protein that accelerates aging (and probably sounds familiar if you saw the HBO documentary "Life According to Sam"). Hibiscus helps skin produce collagen, retinol fights wrinkles, aloe calms inflammation and grape stem cells protect skin from the sun. And there's an overwhelming dossier of research to back it all up.