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Have your "fine" lines begun to etch a deeper groove into your skin -- not to mention psyche -- and started morphing into (cue sinister music) full-blown wrinkles?

Let's be Zen about it. Take pride in each furrow as it represents a hardship overcome. Find joy in every crease as it is like a smile remembered. Ugh, who are we kidding? Let's plump those suckers up!

"The new world of fillers is tremendous for the consumer," says noted dermatologist Kathy Fields, co-founder of skin care brand Rodan & Fields. "[With them], we refresh faces, removing hollows, sags, dents and lines. We can't make anyone a 20-year-old again but we can make people look great for their age."

OK, so you decide you're game for a non-surgical skin treatment like Juvederm, Perlane or Radiesse, but you're wondering which one to use. The advent of safer, longer-lasting injectable fillers has made grandma's gold-standard collagen go the way of the dodo, but with such a glut of choices, women today are like kids with those dang Webkinz -- our minds beleaguered by what to choose and why. Here, we'll explain what the most common non-surgical facial fillers are, and share feedback from readers and doctors on whom they're best for and the pros and cons of each.

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The deal with fillers
Even dermatologists can't agree on which products work best and last longest. Why? Off-setting wrinkles isn't an exact science. Myriad factors -- like skin texture, age and amount of sun damage -- are taken into account before plotting a patient's best course of action when it comes to facial fillers.

But don't stress (seriously, don't -- it causes wrinkles as these expert tips prove). We're gonna walk you through the basics of four commonly used fillers: Restylane, Juvederm, Perlane and Radiesse, so you can make an informed decision. Because prices vary so widely depending on where you live, the doc you see and how much product your specific case requires, we'll leave that research up to you -- the rest is on us.

Next: The facts

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Filler facts
Restylane, Juvederm and Perlane are hyaluronic acid (HA) fillers. HA is a natural sugar compound found in all living organisms that provides volume and fullness to the skin. When injected, the HA molecules draw in water and cause the tissue underneath to swell. They're made of biodegradable non-animal HA and, unlike collagen, pose no risk of allergic reaction or being rejected by the body. Radiesse, on the other hand, is composed of tiny crystals containing calcium hydroxyapatite, a substance found in our bones and teeth. It, too, is manufactured synthetically so there's no risk of having an allergic reaction and thus no need for skin testing before having the product injected.

What the four have in common is the recovery/down time -- itching, redness and/or bruising may occur at the injection site(s). Swelling may last for up to 7 days. And the basic procedure/pain factor: Usually a numbing cream (typically lidocaine) will be applied to the areas that will be injected, but most patients still experience moderate pain while being injected -- especially around the mouth.

Next: The 4-1-1 on Restylane

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Restylane
Restylane has been used in Europe since 1996. The FDA approved it for use in the U.S. in 2003.

It works best on: Nasolabial folds (from the nose to above the lips), smile lines, forehead wrinkles, hollows beneath the eyes and sculpting/plumping lips.

What to expect: A numbing cream will be applied to the areas to be injected but most patients still experience moderate pain while being injected -- especially when using it to plump lips.

How long it lasts: Individual results may vary but six months is typical.

One expert's opinion: Dr. Simona Arcan, co-owner of Skin Savvy in Hermosa Beach, Calif., thinks that Restylane is a great "starter" filler. "If you're looking to plump up but only temporarily, say for a high school reunion or an anniversary cruise, it's great. You can "try on" the look without the long-term commitment of the longer-lasting products."

Reader review: Total Beauty reader Joy told us on Facebook that she did Restylane one time and loved it. "It covered all the wrinkles around my mouth and filled in all the areas that were getting sunk in. I would have it done again but the cost factor prohibit[ed] me."

Next: All about Perlane

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Perlane
Manufactured by the same company, Medicis Aesthetics, Inc., Perlane is Restylane's bigger-particled sister.

It works best on: Because of its larger molecular structure, Perlane needs to be injected deeper, so it works best in the cheeks, chin, eyebrows and around the mouth.

How long it lasts: Perlane is marketed as lasting from nine to 12 months but many pros contend that the duration depends on where it's injected -- an area that doesn't move as much, like cheeks, will reportedly last longer than one that's constantly in motion, like marionette lines (those that run from the corners of your mouth down to your chin).

One expert's opinion: "Perlane is like bread dough," says Dr. Arcan. "It's dense and beautifully moldable so it holds its form and allows you to spread it into the space you want it to go."

Reader review: Total Beauty reader Audrey told us that she had Perlane injected into the "abyss" -- what dermatologists call crevices that occur around the corners of the mouth. "It worked like a charm to plump them back up and lasted for a really long time!"

Next: The info on Juvederm

Have your "fine" lines begun to etch a deeper groove into your skin -- not to mention psyche -- and started morphing into (cue sinister music) full-blown wrinkles?

Let's be Zen about it. Take pride in each furrow as it represents a hardship overcome. Find joy in every crease as it is like a smile remembered. Ugh, who are we kidding? Let's plump those suckers up!

"The new world of fillers is tremendous for the consumer," says noted dermatologist Kathy Fields, co-founder of skin care brand Rodan & Fields. "[With them], we refresh faces, removing hollows, sags, dents and lines. We can't make anyone a 20-year-old again but we can make people look great for their age."

OK, so you decide you're game for a non-surgical skin treatment like Juvederm, Perlane or Radiesse, but you're wondering which one to use. The advent of safer, longer-lasting injectable fillers has made grandma's gold-standard collagen go the way of the dodo, but with such a glut of choices, women today are like kids with those dang Webkinz -- our minds beleaguered by what to choose and why. Here, we'll explain what the most common non-surgical facial fillers are, and share feedback from readers and doctors on whom they're best for and the pros and cons of each.
BY AUDREY FINE | SHARES
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