The Worst Birth Control for Acne On the other side of things, IUDs like Mirena and Skyla made most women's acne worse, as did the Depo-Provera shot, which delivers hormones over a period of 12 weeks.
Of course, this also varied by case. While 36 percent of women surveyed said Mirena made their skin worse, 54 percent said it had no effect, and 10 percent said it helped a little bit or significantly.
If you have tricky skin, you may want to steer clear of long-release forms of birth control because those are progestin-only drugs and are more likely to cause acne, according to Admani. It's easy to quit a daily pill if your skin freaks out, but much harder (and potentially painful) to remove an IUD. The same goes for the depot injection. "Once you get the depot shot, it's in your body. You can't get rid of it," says Admani.
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