40s: Get an Rx for retinol "Retinol is the most important anti-aging ingredient you can use," says New York City dermatologist Jeanette Graf, MD. If you've been dabbing on retinol for decades, your skin probably looks fantastic. But if you've held off for whatever reason (like sensitivity or peeling), now's the time. Especially if you're starting to see crow's feet, frown lines, sun damage or any of those other inevitable signs of aging -- get a prescription, and use it regularly.
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