Filler facts Restylane, Juvederm and Perlane are hyaluronic acid (HA) fillers. HA is a natural sugar compound found in all living organisms that provides volume and fullness to the skin. When injected, the HA molecules draw in water and cause the tissue underneath to swell. They're made of biodegradable non-animal HA and, unlike collagen, pose no risk of allergic reaction or being rejected by the body. Radiesse, on the other hand, is composed of tiny crystals containing calcium hydroxyapatite, a substance found in our bones and teeth. It, too, is manufactured synthetically so there's no risk of having an allergic reaction and thus no need for skin testing before having the product injected.
What the four have in common is the recovery/down time -- itching, redness and/or bruising may occur at the injection site(s). Swelling may last for up to 7 days. And the basic procedure/pain factor: Usually a numbing cream (typically lidocaine) will be applied to the areas that will be injected, but most patients still experience moderate pain while being injected -- especially around the mouth.
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